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Microbiome-based interventions, including fecal microbiota transplantation and defined live biotherapeutics, such as VE303, directly target the gutliverbrain axis and may represent the next generation of HE treatment strategies

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Prescribers and providers must understand that prescribing unlicensed medicines like glutathione outside of a genuine clinical diagnosis and therapeutic need is both dangerous and illegal

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Clinicians should be aware that creatinine-based eGFR may underestimate true kidney function in creatine users

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